Combination of Loop Diuretics With Thiazide-Type Diuretics in Heart Failure
نویسندگان
چکیده
منابع مشابه
Combination of loop diuretics with thiazide-type diuretics in heart failure.
Volume overload is an important clinical target in heart failure management, typically addressed using loop diuretics. An important and challenging subset of heart failure patients exhibit fluid overload despite significant doses of loop diuretics. One approach to overcome loop diuretic resistance is the addition of a thiazide-type diuretic to produce diuretic synergy via "sequential nephron bl...
متن کاملResponsiveness to loop diuretics in heart failure.
Loop diuretics are the most commonly used drugs in the management of pulmonary and systemic congestion in patients with acute decompensated heart failure (ADHF), as well as chronic congestive HF. The diuresis results from blockade of the Na+–K+–Cl2 co-transporter in the ascending limb of the loop of Henle. The pharmacodynamics of loop diuretics are illustrated in Figure 1, and are best describe...
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Thiazide diuretics are widely used for the management of hypertension. In recent years, it has been actively debated that there is interchangeability of thiazide-type diuretics hydrochlorothiazide and thiazide-like diuretics including indapamide and chlorthalidone for the treatment of hypertension. With the purpose of seeking out the best thiazide diuretic for clinicians, we summarized the exis...
متن کاملThiazide diuretics in hypertension
Authors: Ferreira R. The use of diuretics (and beta-blockers) to treat hypertension has known a dramatic decline since the early 1980’s through to the early 1990s with the introduction of ACE-inhibitors and calcium channel blockers. However, thiazide diuretics are still a first line option to treat arterial hypertension, due to their efficacy and cost-effectiveness profile. We have presented ma...
متن کاملPharmacokinetics of loop diuretics in congestive heart failure.
Patients with congestive heart failure (CHF) represent one of the largest groups in which loop diuretics are a mainstay of treatment. Their proper use requires an understanding of the mechanisms of response to diuretics in such patients. Over the past few years information has increased concerning the pharmacokinetics and pharmacodynamics of loop diuretics in various diseases but particularly C...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2010
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2010.06.034